Noncoding RNAs Serve as Diagnosis and Prognosis Biomarkers for Hepatocellular Carcinoma
نویسندگان
چکیده
منابع مشابه
Long Noncoding RNAs Act as Novel Biomarkers for Hepatocellular Carcinoma: Progress and Prospects
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and confers a poor prognosis. Novel diagnostic or prognostic biomarkers and effective therapeutic targets for HCCs are urgently needed. Currently, dozens of long noncoding RNAs (lncRNAs) have been identified as playing critical roles in cancer development and progression. Advanced studies have shown that several well-kno...
متن کاملSerum LncRNAs Profiles Serve as Novel Potential Biomarkers for the Diagnosis of HBV-Positive Hepatocellular Carcinoma
BACKGROUND Hepatocellular carcinoma (HCC) is a common malignancy that has a poor prognosis because there is lack of methods for early diagnosis. We aimed to utilize two serum long non-coding RNAs (lncRNAs), uc001ncr and AX800134, to diagnose hepatitis B virus (HBV)-positive HCC. METHODS lncRNA microarrays were utilized to measure the differential expression of lncRNAs between tumor tissues an...
متن کاملLong Noncoding RNAs as a Key Player in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a major malignancy in the liver and has emerged as one of the main cancers in the world with a high mortality rate. However, the molecular mechanisms of HCC are still poorly understood. Long noncoding RNAs (lncRNAs) have recently come to the forefront as functional non-protein-coding RNAs that are involved in a variety of cellular processes ranging from maintai...
متن کاملLong Noncoding RNAs as Biomarkers in Cancer
Long noncoding RNAs (lncRNAs) are a relatively well-characterized class of noncoding RNA (ncRNA) molecules, involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their deregulation has been associated with the development and progression of various cancer types, the fact which makes them suitable as biomarkers for ca...
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context primary liver cancer is one of the most common and deadly malignant neoplasms worldwide. the incidence and mortality rates for hepatocellular carcinoma (hcc) are virtually identical, reflecting the poor overall survival of patients with this kind of tumor. effective therapies mostly achieved if the hcc diagnosis is made at early stages of the tumor. surveillance tests include serologic ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2019
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2018.301150